- MSM is a natural and safe nutritional supplement that is achieving skyrocketing notoriety because of the many types of pain and swelling complaints it is able to address successfully. – MSM is already recognized as a safe and virtually side-effect-free supportive for addressing painful and inflamed complaints, including stiffness, ongoing back pain, ongoing headache, muscle pain, muscle pain, tendonitis, bursitis, carpal tunnel syndrome, TMJ, post-traumatic pain and swelling, scleroderma, and